Drug delivery systems are designed to increase the bioavailability of drugs, control drug release, and ensure the drug’s intact transport to the site of action while avoiding non-diseased tissues. The development of GalNAc conjugates, which bind to the asialoglycoprotein receptor, has become a revolutionary approach for the targeted delivery of therapeutic oligonucleotides to hepatocytes.

In addition to GalNAc conjugates, lipid-based drug delivery systems are evolving technologies aimed at addressing challenges such as the solubility and bioavailability of poorly water-soluble drugs.

Sapala has extensive experience in synthesizing a wide variety of triantennary and monoantennary GalNAc derivatives with various linkers and dendrimer subunits. Additionally, Sapala has demonstrated expertise in synthesizing multiple lipids, including cationic lipids and phospholipids used in drug delivery systems.